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This process involves the coordinated interplay among osteoblasts, mesenchymal stem cells, endothelial cells, and products of the bone microenvironment ( In recent years, natural bioactive productsparticularly those derived from traditional botanical drughave emerged as promising candidates for modulating bone remodeling due to their favorable biocompatibility, low toxicity, and pleiotropic pharmacological activities ( Building upon these mechanistic insights, this review aims to provide a systematic overview of recent advances in the application of natural bioactive products for OP therapy, with a particular emphasis on their roles in promoting bone regeneration

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Furthermore, new approaches to blockade of signaling mediated by bioactive TNF might have the potential to generate higher-magnitude clinical responses than are currently elicited